Theoretical Analysis

Chemical Formula: C187H291N45O59
Molecular Mass: 4113.6
Synonyms: Semaglutide, NN9535
Molar Mass: 4113.6
CAS Number: 910463-68-2
PubChem: 56843331
Vial Size: 3ml
Vial Contents: Lyophilized Powder (>99% purity)

Description

Chemical Structure: Semaglutide

IUPAC/Chemical Name:
L-histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-glycine, sodium salt

Semaglutide Overview

Semaglutide is a synthetic analog of the human glucagon-like peptide-1 (GLP-1), a hormone involved in regulating blood sugar levels by enhancing insulin secretion. It is a long-acting compound designed to mimic the effects of the naturally occurring hormone, but with modifications that extend its duration of action and stability in the human body. Semaglutide is unique due to its acylation with a fatty acid, which allows it to bind to albumin in the bloodstream, slowing down its degradation and prolonging its action.

Key Features and Benefits:

• Blood Sugar Regulation: Semaglutide enhances insulin secretion in response to elevated blood glucose levels, aiding in the regulation of blood sugar.
• Long-Acting: The fatty acid acylation allows for prolonged action and stability in the body by binding to albumin.
• Research and Therapeutic Potential: In addition to its role in diabetes management, semaglutide has potential applications in weight management and other metabolic disorders.
• Same Active Ingredient as Ozempic: Semaglutide is the same active drug found in the commercially available medication Ozempic, used for treating type 2 diabetes and aiding in weight loss.

Research Uses and Mechanism of Action Studies

In research studies, semaglutide can be used to investigate a variety of scientific questions related to its mechanism of action, pharmacokinetics (the study of how the body absorbs, distributes, metabolizes, and excretes a drug), and pharmacodynamics (the study of the biochemical and physiological effects of drugs and their mechanisms of action). For example, it can be employed in studies aimed at understanding the role of GLP-1 in glucose homeostasis and metabolic processes. Research can also explore how modifications to the GLP-1 molecule, like those found in semaglutide, affect its interaction with the GLP-1 receptor and its stability and activity in the body.

Cellular and Molecular Research

Research involving semaglutide can also delve into its effects on cellular signaling pathways, gene expression, and the secretion of hormones related to glucose metabolism and appetite regulation. By studying these mechanisms, researchers can gain insights into the broader physiological roles of GLP-1 and its analogs, potentially uncovering new applications for these compounds in the treatment of diseases beyond diabetes.

Product Usage

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY.
This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation. All product information available on this website is for educational purposes only.

Important Usage Information:

• Bodily Introduction: Any form of bodily introduction into humans or animals is strictly forbidden by law.
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