FOXO4-DRI (Fox-04) Peptide: Laboratory Research Overview

An educational overview of FOXO4-DRI peptide in cellular senescence research for laboratory use only.

Overview

FOXO4-DRI, also known as Fox-04 or Proxofim, is a synthetic peptide investigated in controlled laboratory environments for its interactions with cellular pathways related to senescence. It is not approved for human, animal, or clinical use.

Scientific Background

  • Type: D-Retro-Inverso (DRI) peptide analog
  • Primary Study Focus: Cellular senescence and apoptosis signaling pathways
  • Structure: Modified for stability in research models
  • Status: Laboratory research only

Mechanism of Action (Research Context)

In laboratory studies, FOXO4-DRI interacts with p53-related signaling pathways that influence cell survival in preclinical models. These findings are strictly limited to in vitro and ex vivo research and are not indicative of human outcomes.

Research Use Guidelines

For laboratory research only. FOXO4-DRI is not intended for human or veterinary use, drug manufacturing, or dietary consumption. All information is provided for educational purposes for scientific and institutional research professionals.

Ongoing Laboratory Studies

  • Investigation of senescence regulation and apoptosis mechanisms
  • Interactions with cellular stress response systems in preclinical models
  • Optimization of peptide sequence for reproducibility in laboratory experiments

Access Research-Grade FOXO4-DRI

Research-grade FOXO4-DRI (Fox-04) peptide is available to qualified institutions and laboratories conducting non-clinical, educational research.

Request Research Access

Selected References

  1. Zhang, X. et al. (2023). “FOXO4 peptide and senescent cell signaling.” Gene & Protein in Disease.
  2. Bourgeois, C. et al. (2018). “Senescence modulation through FOXO4 interaction.” FEBS Letters.

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