GLP-1 Dosage Schedule Calculator + Weight Loss Calculator
How GLP-1 Peptides Work
All peptides target hunger and metabolism, but they don't do it the same way. Here's the complete lineup ranked by effectiveness:
- Retatrutide (~24.2% weight loss) Triple agonist (GLP-1, GIP, glucagon). Burns fat, crushes appetite, and boosts energy. The "triple threat" is the 13-pound swimbait of weight loss—massive, aggressive, and built to reel in fat fast. Still in trials, but easily the biggest heavyweight on the list.
- CagriSema (~20–23% weight loss) A killer combo of semaglutide and cagrilintide. You get two powerful hunger-regulating hormones hitting your brain from different angles. Outperforms both ingredients on their own—without needing massive doses. The appetite suppression is next level.
- Tirzepatide (~19–21% weight loss) Dual agonist (GLP-1 + GIP). Think of it as semaglutide with rocket fuel. Weekly injections. FDA-approved. It's already changing the game for obesity, and it works even if you're not starving yourself.
- Semaglutide/Wegovy (~15% body weight loss, up to 20% in high-dose trials) The gold standard GLP-1. Slows digestion, reduces hunger, and improves blood sugar. Solid and consistent, but it's starting to feel like the older cousin compared to the newer dual and triple agonists.
- Mazdutide (~10–15% weight loss) GLP-1 + glucagon dual agonist. Cranks up your metabolism while dialing down hunger. Still in Phase 3 trials but showing real promise as a metabolism-revving fat burner.
- Survodutide (~12% weight loss over 46 weeks) Another GLP-1 + glucagon dual agonist. Also making waves in trials for treating fatty liver (MASH). Still experimental but putting up strong numbers and doing work on both external and internal fat.
- Caligrutide (~9–16 lbs lost) New GLP-1 agonist in development. Might be easier on the stomach than semaglutide, but data is limited. So far, it's more of a slow-and-steady option—less flash, fewer side effects.
- Liraglutide/Saxenda (~5–7% weight loss) The OG GLP-1. Daily injection, modest results. It's no longer the standout it once was, but it's reliable and still gets the job done for some. Basically the VHS tape of GLP-1s—classic, but showing its age.
Complete Dose Schedules + Weight Loss Data
| Peptide | Type | Titration Schedule | Weight Loss |
|---|---|---|---|
| Retatrutide | Triple agonist | 1.5 → 3 → 6 → 9 → 12 mg (weekly or biweekly) | ~24.2% body weight |
| CagriSema | Combo therapy | 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg each (every 4 wks) | ~20–23% body weight |
| Tirzepatide | Dual agonist | 2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg (every 4 wks) | ~19–21% body weight |
| Semaglutide | GLP-1 only | 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg (every 4 wks) | ~15% body weight |
| Mazdutide | Dual agonist | 3 → 6 → 9 → 10 mg (every 4 wks) | ~10–15% body weight |
| Survodutide | Dual agonist | 0.6 → 2.4 → 3.6 → 4.8 mg (over 20 wks) | ~12% body weight |
| Caligrutide | GLP-1 only | Follows semaglutide-style titration | 9–16 lbs |
| Liraglutide | GLP-1 only | 0.6 → 1.2 → 1.8 → 2.4 → 3.0 mg DAILY | ~5–7% body weight |
Realistic Expectations by Peptide
- 2–5 lbs/week with Retatrutide (triple threat)
- 2–4 lbs/week with CagriSema (dual suppression)
- 1.5–3 lbs/week with Tirzepatide
- 1–2 lbs/week with Semaglutide
- 1–2.5 lbs/week with Mazdutide or Survodutide
- 0.5–1 lb/week with Liraglutide (daily injections)
- Plateau after ~16–20 weeks is common, then taper or rotate
Important Notes
- Injection Frequency: All are weekly injections except Liraglutide (daily)
- FDA Status: Only Semaglutide, Tirzepatide, and Liraglutide are FDA-approved for weight loss
- Trial Stage: Retatrutide, Mazdutide, Survodutide, and Caligrutide are still in clinical trials
- Side Effects: All can cause nausea, especially during titration. Start low, go slow
Final Word
The new generation of dual and triple agonists (Retatrutide, CagriSema, Tirzepatide) are absolutely crushing the weight loss game. Even "old reliable" Semaglutide holds its ground with consistent results. The future of medical weight loss is here—and it's more effective than ever.
Research use only. We do not condone human or animal use. Always consult with a healthcare professional.
BMI Calculator (Body Mass Index)
Figuring out your body mass index (BMI) is a good way to determine if you're at a healthy weight or if your idea of exercise is a trip to the fridge. The BMI calculator can also determine if you are underweight. Of course, please keep in mind this does not apply to people who are bodybuilders. The medical community uses BMI as a screening tool to assess if you are at risk for diabetes, cancer (which mainly feeds on sugar), and heart disease.
- Underweight: BMI less than 18.5
- Perfect Normal Weight: BMI 18.5 to 24.9
- Overweight: BMI 25 to 29.9
- Obesity: BMI 30 or more