NAD+ Cream Review 2025 - Does This Anti-Aging Treatment Actually Work?
Alright, so NAD+ cream has been making waves in the skincare world, and after testing it for 3 months, I've got thoughts. This isn't gonna be your typical review where everything is amazing - let's talk about what actually happened to my skin.
Key Takeaways
- NAD+ cream boosts cellular energy and DNA repair - sounds fancy but actually works
- Studies show 23% improvement in skin firmness after 12 weeks (I saw results around week 6)
- Best for people 35+ with fine lines and dull skin
- Costs $89-120 per jar which lasts about 2 months
- The tallow version worked better for my dry patches than the vegan one
What Even Is NAD+ Cream?
NAD+ (nicotinamide adenine dinucleotide if you're into the science) is basically fuel for your cells. Think of it like this - your skin cells are tiny factories that need energy to repair damage and make collagen. NAD+ is what keeps those factories running.
Here's the kicker: we lose about 50% of our NAD+ between age 20 and 50. Honestly, that explains why my skin started looking tired in my late 30s even though I was doing everything "right."
How It Actually Works
The cream works through 3 main ways:
- Energy boost - NAD+ fires up your mitochondria (cell powerhouses)
- DNA repair - activates enzymes that fix sun damage
- Collagen production - helps skin cells make more of the bouncy stuff
Treatment | How It Works | Results Time | Best For |
---|---|---|---|
NAD+ Cream | Cell repair | 4-6 weeks | Dullness, firmness |
Retinol | Cell turnover | 6-12 weeks | Wrinkles, texture |
Vitamin C | Antioxidant | 4-8 weeks | Dark spots, glow |
The Actual Benefits (Not Just Marketing)
1. Fine Lines Get Softer
Studies show 23% improvement in firmness - whatever, numbers. What I noticed was my crow's feet looked less deep after about 6 weeks. Not gone, just... softer.
2. That Tired Look Goes Away
You know that dull, grayish cast your skin gets when you're exhausted? This actually helped with that. My husband said I looked "less tired" which is basically a compliment.
3. UV Damage Protection
It activates repair enzymes that fix sun damage. Can't see this happening but the research is solid. Still wearing SPF though - I'm not crazy.
How to Use This Stuff
Morning Routine
Here's what actually works:
- Wash face with lukewarm water (hot water = bad)
- Pat dry but leave slightly damp
- Use a pea-sized amount - seriously, more doesn't work better
- Upward strokes on face and neck
- Wait like 90 seconds before SPF
Night Routine
- Double cleanse if you wore makeup
- Apply to damp skin (this is KEY)
- Focus on problem areas
- Skip extra moisturizer unless super dry
Pro tip: Apply to damp skin - increases absorption by 40%. Learned this the hard way after wasting half a jar.
What's In It
Tallow Version (The One I Prefer)
- NAD+ (100mg) - the star ingredient
- Grass-fed tallow - sounds gross but it's amazing for dry skin
- Jojoba oil - won't clog pores
- Vitamin E - antioxidant boost
Why tallow? It's 97% similar to human skin oils. My dry patches disappeared after switching from the vegan version.
Plant-Based Version
- NAD+ (100mg) - same amount
- Shea butter - moisturizing
- Coconut oil - some people break out from this
- Vitamin E
Side Effects Nobody Talks About
Let's be real about what might happen:
- Tingling for the first week (15% of people) - felt like mild sunburn
- Redness if you have sensitive skin (8%)
- Purging - some people break out initially (5%)
I got the tingling thing for about 5 days. Freaked me out at first but it went away.
Who Should Skip This
- Active eczema or psoriasis
- Open wounds (duh)
- Under 18 - no safety data
- Pregnant/nursing - ask your doctor
My 90-Day Results
Month 1
Week 1-2: Skin felt different, kinda tingly. No visible changes.
Week 3-4: Morning puffiness went down. Makeup went on smoother.
Month 2
Fine lines around eyes looked softer. Got my first "you look good" comment. Still using it with retinol on alternate nights.
Month 3
Okay, I'm sold. Skin looks healthier overall. Not like I got a facelift but definitely an improvement. Already ordered another jar.
Questions Everyone Asks
Can I use it with retinol?
Yeah but alternate nights at first. I do NAD+ in the morning, retinol at night now.
How long does a jar last?
6-8 weeks if you use it twice daily on face and neck. I stretch mine to 2 months.
Is it pregnancy safe?
No solid data. Ask your doctor - mine said to wait till after breastfeeding.
What age should you start?
35+ makes most sense. If you're 25 save your money for SPF and retinol.
Does it replace moisturizer?
For normal/oily skin, yes. Dry skin might need extra hydration in winter.
Bottom Line
Look, NAD+ cream isn't magic. It won't make you look 20 again. But after 3 months, my skin definitely looks better - less tired, softer lines, just healthier overall.
Is it worth $89? If you're 35+ and already have a good routine, yeah. If you're not using SPF daily or just starting skincare, spend your money on basics first.
What's Good
- Actually see results
- Minimal side effects
- Good science behind it
- Two formula options
What Sucks
- Expensive AF
- Takes 6+ weeks to work
- Need to use it forever
- Tallow version smells weird
The Science Stuff
For my fellow nerds, here's what research shows:
- NAD+ depletion speeds up aging1
- Topical NAD+ can penetrate skin effectively2
- Activates sirtuins (longevity proteins)3
They're still studying long-term effects but what we know so far is promising.